This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for MOK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MOK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MOK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:101,947,631–101,948,934 | 356.9 kb | Distal (>10kb) Multiome | 984 | |
| chr14:101,963,949–101,965,702 | 340.7 kb | Distal (>10kb) Multiome | 798 | |
| chr14:102,046,172–102,046,761 | 258.6 kb | Distal (>10kb) Multiome | 326 | |
| chr14:102,086,286–102,088,835 | 218.0 kb | Distal (>10kb) Multiome | 1052 | |
| chr14:102,097,398–102,098,067 | 207.5 kb | Distal (>10kb) Multiome | 159 | |
| chr14:102,139,026–102,140,960 | 165.5 kb | Distal (>10kb) Multiome | 844 | |
| chr14:102,235,389–102,235,598 | at TSS | At TSS | 279 | |
| chr14:102,247,845–102,248,746 | 56.8 kb | Distal (>10kb) Multiome HiCAR | 142 | |
| chr14:102,304,511–102,305,687 | 7 bp | At TSS Multiome HiCAR | 568 | |
| chr14:102,314,028–102,314,685 | 9.2 kb | Proximal (<10kb) Multiome HiCAR | 720 | |
| chr14:102,316,590–102,317,741 | 12.0 kb | Distal (>10kb) Multiome HiCAR | 885 | |
| chr14:102,319,368–102,320,458 | 14.6 kb | Distal (>10kb) Multiome HiCAR | 675 | |
| chr14:102,362,620–102,363,583 | 57.8 kb | Distal (>10kb) Multiome | 705 | |
| chr14:102,507,117–102,508,097 | 202.5 kb | Distal (>10kb) Multiome | 100 | |
| chr14:102,508,416–102,511,398 | 204.7 kb | Distal (>10kb) Multiome | 778 | |
| chr14:102,516,500–102,517,914 | 211.8 kb | Distal (>10kb) Multiome | 694 | |
| chr14:102,524,045–102,525,126 | 219.6 kb | Distal (>10kb) Multiome | 817 | |
| chr14:102,545,130–102,546,123 | 240.6 kb | Distal (>10kb) Multiome | 458 | |
| chr14:102,554,738–102,555,873 | 250.4 kb | Distal (>10kb) Multiome | 280 | |
| chr14:102,585,306–102,585,775 | 280.4 kb | Distal (>10kb) Multiome | 259 | |
| chr14:102,591,431–102,593,846 | 287.3 kb | Distal (>10kb) Multiome | 895 |
Genomic view of the MOK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.