This gene encodes an enzyme that sulfurates the molybdenum cofactor which is required for activation of the xanthine dehydrogenase (XDH) and aldehyde oxidase (AO) enzymes. XDH catalyzes the conversion of hypoxanthine to uric acid via xanthine, as well as the conversion of allopurinol to oxypurinol, and pyrazinamide to 5-hydroxy pyrazinamide. Mutations in this gene cause the metabolic disorder classical xanthinuria type II which is characterized by the loss of XDH/XO and AO enzyme activity, decreased levels of uric acid in the urine, increased levels of xanthine and hypoxanthine in the serum and urine, formation of xanthine stones in the urinary tract, and myositis due to tissue deposition of xanthine. [provided by RefSeq, Apr 2017]
Transcription factors with Perturb-seq knockdown data for MOCOS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MOCOS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MOCOS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:35,949,718–35,950,700 | 237.1 kb | Distal (>10kb) Multiome | 420 | |
| chr18:35,971,798–35,973,006 | 215.0 kb | Distal (>10kb) Multiome | 1056 | |
| chr18:36,066,875–36,067,975 | 119.9 kb | Distal (>10kb) Multiome | 832 | |
| chr18:36,128,266–36,130,354 | 57.9 kb | Distal (>10kb) Multiome | 1064 | |
| chr18:36,186,392–36,188,500 | 91 bp | At TSS Multiome | 747 | |
| chr18:36,189,006–36,189,191 | 1.5 kb | Proximal (<10kb) | 53 | |
| chr18:36,296,503–36,298,742 | 110.1 kb | Distal (>10kb) Multiome | 532 |
Genomic view of the MOCOS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.