The product of the MND1 gene associates with HOP2 (MIM 608665) to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1 (MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1 and HOP2 genes are indispensable for meiotic recombination.[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for MND1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MND1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MND1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:153,083,338–153,083,974 | 261.1 kb | Distal (>10kb) Multiome | 317 | |
| chr4:153,125,863–153,126,388 | 218.6 kb | Distal (>10kb) Multiome | 64 | |
| chr4:153,152,013–153,153,918 | 191.2 kb | Distal (>10kb) Multiome HiCAR | 646 | |
| chr4:153,204,222–153,207,340 | 138.9 kb | Distal (>10kb) Multiome | 625 | |
| chr4:153,222,243–153,223,345 | 122.0 kb | Distal (>10kb) Multiome | 755 | |
| chr4:153,248,554–153,249,897 | 95.4 kb | Distal (>10kb) Multiome | 489 | |
| chr4:153,344,063–153,345,542 | 14 bp | At TSS Multiome | 920 | |
| chr4:153,348,081–153,348,551 | 3.4 kb | Proximal (<10kb) | 128 | |
| chr4:153,452,038–153,452,864 | 107.7 kb | Distal (>10kb) Multiome | 245 | |
| chr4:153,465,572–153,467,737 | 121.6 kb | Distal (>10kb) Multiome | 862 | |
| chr4:153,536,072–153,536,529 | 191.6 kb | Distal (>10kb) Multiome | 95 | |
| chr4:153,759,037–153,760,663 | 415.2 kb | Distal (>10kb) Multiome HiCAR | 280 |
Genomic view of the MND1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.