MMS19
MMS19 cytosolic iron-sulfur assembly component | CIAO4, MET18, hMMS19, MMS19L

Enables nuclear estrogen receptor binding activity and transcription coactivator activity. Involved in protein maturation. Located in cytosol; nucleoplasm; and spindle. Part of MMXD complex and cytosolic [4Fe-4S] assembly targeting complex. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-10
Biological processes 28 terms
MMXD complex (GO:0071817)MMXD complex (GO:0071817)centrosome (GO:0005813)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosolic [4Fe-4S] assembly targeting complex (GO:0097361)cytosolic [4Fe-4S] assembly targeting complex (GO:0097361)cytosolic [4Fe-4S] assembly targeting complex (GO:0097361)enzyme binding (GO:0019899)iron-sulfur cluster assembly (GO:0016226)membrane (GO:0016020)nuclear estrogen receptor binding (GO:0030331)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)protein binding (GO:0005515)protein maturation (GO:0051604)protein maturation (GO:0051604)protein maturation (GO:0051604)protein maturation (GO:0051604)protein-macromolecule adaptor activity (GO:0030674)signaling receptor complex adaptor activity (GO:0030159)spindle (GO:0005819)spindle (GO:0005819)transcription coactivator activity (GO:0003713)transcription factor TFIIH holo complex (GO:0005675)
Expression (TPM)
MMS19 — as a Regulated Gene

TFs regulating MMS19 0 TFs

Transcription factors with Perturb-seq knockdown data for MMS19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MMS19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to MMS19

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MMS19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr10:97,291,972–97,293,103 205.7 kb Distal (>10kb) Multiome 945
chr10:97,318,840–97,320,386 179.2 kb Distal (>10kb) Multiome 836
chr10:97,333,472–97,335,742 163.5 kb Distal (>10kb) Multiome 917
chr10:97,336,929–97,337,706 161.1 kb Distal (>10kb) Multiome 362
chr10:97,400,817–97,401,691 97.1 kb Distal (>10kb) Multiome 644
chr10:97,407,246–97,407,739 90.9 kb Distal (>10kb) Multiome 539
chr10:97,418,830–97,419,461 79.3 kb Distal (>10kb) Multiome 323
chr10:97,425,050–97,426,796 72.3 kb Distal (>10kb) Multiome 715
chr10:97,445,521–97,446,585 52.3 kb Distal (>10kb) Multiome 802
chr10:97,495,201–97,495,487 2.9 kb Proximal (<10kb) 53
chr10:97,497,718–97,499,773 280 bp At TSS Multiome 967
chr10:97,553,598–97,554,047 55.4 kb Distal (>10kb) Multiome 340
chr10:97,632,775–97,633,915 135.1 kb Distal (>10kb) Multiome 725
chr10:97,640,236–97,641,335 142.2 kb Distal (>10kb) Multiome 712
chr10:97,686,724–97,687,987 189.0 kb Distal (>10kb) Multiome 993
chr10:97,713,223–97,715,263 215.4 kb Distal (>10kb) Multiome 639
chr10:97,736,595–97,737,824 238.7 kb Distal (>10kb) Multiome 1009
chr10:97,771,123–97,772,389 273.3 kb Distal (>10kb) Multiome 356
chr10:97,788,725–97,789,448 290.7 kb Distal (>10kb) Multiome 398

Genome Browser

Genomic view of the MMS19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr10:97,281,972 – 97,799,448
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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