This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. Unlike most MMPs, which are secreted, this protease is a member of the membrane-type MMP (MT-MMP) subfamily, contains a transmembrane domain and is expressed at the cell surface. Substrates of this protease include the proteins cadherin 2 and matrix metallopeptidase 2 (also known as 72 kDa type IV collagenase). The gene has previously been referred to as MMP25 but has been renamed matrix metallopeptidase 24 (MMP24). [provided by RefSeq, Oct 2019]
Transcription factors with Perturb-seq knockdown data for MMP24. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MMP24 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MMP24, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:34,955,039–34,956,224 | 270.9 kb | Distal (>10kb) Multiome | 1031 | |
| chr20:34,960,537–34,961,054 | 265.8 kb | Distal (>10kb) Multiome | 275 | |
| chr20:34,979,568–34,980,289 | 246.8 kb | Distal (>10kb) Multiome | 149 | |
| chr20:35,092,320–35,093,398 | 133.9 kb | Distal (>10kb) Multiome | 1139 | |
| chr20:35,146,563–35,147,734 | 79.4 kb | Distal (>10kb) Multiome | 992 | |
| chr20:35,171,731–35,172,358 | 54.7 kb | Distal (>10kb) Multiome | 383 | |
| chr20:35,174,680–35,175,277 | 51.7 kb | Distal (>10kb) Multiome | 635 | |
| chr20:35,227,055–35,227,291 | 366 bp | At TSS | 671 | |
| chr20:35,262,839–35,263,582 | 36.6 kb | Distal (>10kb) Multiome | 336 | |
| chr20:35,269,197–35,269,766 | 42.8 kb | Distal (>10kb) Multiome | 447 | |
| chr20:35,277,415–35,278,519 | 51.4 kb | Distal (>10kb) Multiome | 575 | |
| chr20:35,284,235–35,285,360 | 58.1 kb | Distal (>10kb) Multiome | 950 | |
| chr20:35,303,859–35,304,479 | 77.4 kb | Distal (>10kb) Multiome | 484 | |
| chr20:35,454,521–35,455,845 | 228.5 kb | Distal (>10kb) Multiome | 1059 |
Genomic view of the MMP24 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.