The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MLYCD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MLYCD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MLYCD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:83,807,528–83,808,459 | 91.2 kb | Distal (>10kb) Multiome | 733 | |
| chr16:83,840,075–83,841,171 | 58.6 kb | Distal (>10kb) Multiome | 136 | |
| chr16:83,888,352–83,889,387 | 10.3 kb | Distal (>10kb) Multiome | 237 | |
| chr16:83,898,559–83,899,828 | 97 bp | At TSS Multiome | 773 | |
| chr16:83,926,399–83,927,376 | 27.7 kb | Distal (>10kb) Multiome | 532 | |
| chr16:83,968,110–83,968,725 | 69.3 kb | Distal (>10kb) Multiome | 261 | |
| chr16:84,013,600–84,015,009 | 115.1 kb | Distal (>10kb) Multiome | 388 | |
| chr16:84,043,411–84,043,885 | 144.6 kb | Distal (>10kb) Multiome | 292 | |
| chr16:84,062,518–84,063,095 | 163.8 kb | Distal (>10kb) Multiome | 330 | |
| chr16:84,116,331–84,117,716 | 217.8 kb | Distal (>10kb) Multiome | 1013 | |
| chr16:84,144,637–84,145,742 | 246.1 kb | Distal (>10kb) Multiome | 679 | |
| chr16:84,186,615–84,187,246 | 287.9 kb | Distal (>10kb) Multiome | 848 |
Genomic view of the MLYCD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.