Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MIX23. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIX23 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIX23, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:121,545,326–121,546,305 | 837.3 kb | Distal (>10kb) Multiome HiCAR | 673 | |
| chr3:122,183,580–122,184,993 | 198.9 kb | Distal (>10kb) Multiome | 224 | |
| chr3:122,382,880–122,383,692 | 169 bp | At TSS Multiome | 711 | |
| chr3:122,383,843–122,384,747 | 999 bp | At TSS Multiome | 937 | |
| chr3:122,390,522–122,390,974 | 7.3 kb | Proximal (<10kb) | 79 | |
| chr3:122,442,936–122,443,707 | 60.1 kb | Distal (>10kb) Multiome | 134 | |
| chr3:122,514,019–122,515,266 | 131.6 kb | Distal (>10kb) Multiome | 888 | |
| chr3:122,564,086–122,564,854 | 181.2 kb | Distal (>10kb) Multiome | 849 | |
| chr3:122,680,509–122,681,348 | 297.8 kb | Distal (>10kb) Multiome | 567 |
Genomic view of the MIX23 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.