Enables identical protein binding activity. Predicted to be involved in CENP-A containing chromatin assembly and chromosome segregation. Predicted to act upstream of or within pericentric heterochromatin organization and protein localization to chromosome, centromeric region. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MIS18A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIS18A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIS18A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:32,142,536–32,143,080 | 136.2 kb | Distal (>10kb) Multiome | 39 | |
| chr21:32,278,475–32,279,634 | 27 bp | At TSS Multiome | 828 | |
| chr21:32,305,933–32,306,620 | 27.2 kb | Distal (>10kb) Multiome | 126 | |
| chr21:32,392,560–32,393,703 | 114.0 kb | Distal (>10kb) Multiome | 812 | |
| chr21:32,412,001–32,413,390 | 133.8 kb | Distal (>10kb) Multiome | 469 | |
| chr21:32,432,983–32,433,635 | 154.3 kb | Distal (>10kb) Multiome | 99 | |
| chr21:32,569,288–32,570,076 | 290.7 kb | Distal (>10kb) Multiome | 731 |
Genomic view of the MIS18A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.