Predicted to be involved in several processes, including hormone biosynthetic process; prolactin metabolic process; and regulation of DNA-binding transcription factor activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MIR205HG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIR205HG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIR205HG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:207,751,438–207,753,038 | 1676.8 kb | Distal (>10kb) Multiome HiCAR | 886 | |
| chr1:209,157,018–209,159,115 | 269.9 kb | Distal (>10kb) Multiome | 248 | |
| chr1:209,199,462–209,200,164 | 228.8 kb | Distal (>10kb) Multiome | 90 | |
| chr1:209,305,094–209,305,904 | 123.2 kb | Distal (>10kb) Multiome | 25 | |
| chr1:209,397,758–209,398,927 | 30.7 kb | Distal (>10kb) Multiome | 231 | |
| chr1:209,427,749–209,429,011 | 219 bp | At TSS Multiome | 272 | |
| chr1:209,433,038–209,433,765 | 4.6 kb | Proximal (<10kb) Multiome | 214 | |
| chr1:209,435,340–209,435,999 | 6.5 kb | Proximal (<10kb) | 196 | |
| chr1:209,491,561–209,492,248 | 63.1 kb | Distal (>10kb) Multiome | 104 | |
| chr1:209,565,881–209,566,600 | 137.4 kb | Distal (>10kb) Multiome | 193 | |
| chr1:209,627,346–209,628,178 | 199.0 kb | Distal (>10kb) Multiome | 368 | |
| chr1:211,258,333–211,261,113 | 1830.5 kb | Distal (>10kb) Multiome HiCAR | 1149 |
Genomic view of the MIR205HG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.