Transcription factors with Perturb-seq knockdown data for MIR181A2HG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIR181A2HG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIR181A2HG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:124,415,161–124,415,813 | 242.9 kb | Distal (>10kb) Multiome | 779 | |
| chr9:124,419,615–124,420,013 | 238.7 kb | Distal (>10kb) Multiome | 266 | |
| chr9:124,449,997–124,450,901 | 208.0 kb | Distal (>10kb) Multiome | 232 | |
| chr9:124,453,124–124,454,077 | 204.7 kb | Distal (>10kb) Multiome | 218 | |
| chr9:124,477,322–124,478,654 | 180.4 kb | Distal (>10kb) Multiome | 223 | |
| chr9:124,482,335–124,482,814 | 175.8 kb | Distal (>10kb) Multiome | 94 | |
| chr9:124,504,291–124,505,297 | 153.4 kb | Distal (>10kb) Multiome | 187 | |
| chr9:124,658,127–124,658,461 | at TSS | At TSS | 361 | |
| chr9:124,659,103–124,659,434 | 692 bp | At TSS | 603 | |
| chr9:124,769,647–124,772,472 | 113.1 kb | Distal (>10kb) Multiome | 1006 | |
| chr9:124,776,976–124,778,058 | 118.9 kb | Distal (>10kb) Multiome | 349 | |
| chr9:124,779,329–124,780,041 | 121.3 kb | Distal (>10kb) Multiome | 260 | |
| chr9:124,810,709–124,811,373 | 152.6 kb | Distal (>10kb) Multiome | 209 | |
| chr9:124,839,680–124,840,329 | 181.5 kb | Distal (>10kb) Multiome | 218 | |
| chr9:124,852,683–124,853,882 | 194.8 kb | Distal (>10kb) Multiome | 666 | |
| chr9:124,855,555–124,856,920 | 197.8 kb | Distal (>10kb) Multiome | 402 | |
| chr9:124,861,378–124,862,662 | 203.6 kb | Distal (>10kb) Multiome | 947 | |
| chr9:124,868,442–124,869,814 | 210.7 kb | Distal (>10kb) Multiome | 849 | |
| chr9:124,940,496–124,941,902 | 282.7 kb | Distal (>10kb) Multiome | 979 |
Genomic view of the MIR181A2HG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.