The product of this gene performs the final step in processing a specific class of nuclear-encoded proteins targeted to the mitochondrial matrix or inner membrane. This protein is primarily involved in the maturation of oxidative phosphorylation (OXPHOS)-related proteins. This gene may contribute to the functional effects of frataxin deficiency and the clinical manifestations of Friedreich ataxia. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MIPEP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIPEP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIPEP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:23,466,173–23,466,976 | 422.8 kb | Distal (>10kb) Multiome HiCAR | 601 | |
| chr13:23,578,554–23,580,035 | 310.1 kb | Distal (>10kb) Multiome HiCAR | 775 | |
| chr13:23,599,048–23,599,905 | 289.8 kb | Distal (>10kb) Multiome | 286 | |
| chr13:23,630,212–23,631,077 | 258.8 kb | Distal (>10kb) Multiome | 302 | |
| chr13:23,881,121–23,881,754 | 7.6 kb | Proximal (<10kb) | 44 | |
| chr13:23,888,469–23,890,045 | 18 bp | At TSS Multiome | 802 | |
| chr13:24,159,900–24,161,674 | 271.3 kb | Distal (>10kb) Multiome | 617 |
Genomic view of the MIPEP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.