The protein encoded by this gene contains a caspase-associated recruitment domain and may function in apoptosis. It has been identified as a tumor suppressor in lung and gastric cancers, and a polymorphism in the gene may be associated with gastric cancer risk. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for MINDY3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MINDY3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MINDY3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:15,802,138–15,802,908 | 58.0 kb | Distal (>10kb) Multiome | 244 | |
| chr10:15,856,555–15,857,325 | 3.6 kb | Proximal (<10kb) Multiome | 264 | |
| chr10:15,859,871–15,860,810 | 62 bp | At TSS Multiome | 695 | |
| chr10:16,558,869–16,559,824 | 698.8 kb | Distal (>10kb) Multiome HiCAR | 57 | |
| chr10:16,816,770–16,818,262 | 957.0 kb | Distal (>10kb) Multiome HiCAR | 801 | |
| chr10:17,228,175–17,230,908 | 1369.9 kb | Distal (>10kb) Multiome HiCAR | 920 |
Genomic view of the MINDY3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.