MICB

MHC class I polypeptide-related sequence B | PERB11.2

This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Developmental clusters: GC1

Biological processes 19 terms

cell surface (GO:0009986)external side of plasma membrane (GO:0009897)extracellular region (GO:0005576)gamma-delta T cell activation (GO:0046629)gamma-delta T cell activation (GO:0046629)gamma-delta T cell activation (GO:0046629)immune response (GO:0006955)immune response-activating cell surface receptor signaling pathway (GO:0002429)natural killer cell lectin-like receptor binding (GO:0046703)natural killer cell lectin-like receptor binding (GO:0046703)negative regulation of defense response (GO:0031348)negative regulation of defense response to virus by host (GO:0050689)plasma membrane (GO:0005886)plasma membrane (GO:0005886)regulation of immune response (GO:0050776)response to heat (GO:0009408)response to heat (GO:0009408)response to oxidative stress (GO:0006979)response to retinoic acid (GO:0032526)

Expression (TPM)

TFs regulating MICB 0 TFs

Transcription factors with Perturb-seq knockdown data for MICB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MICB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MICB

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MICB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:31,307,823–31,308,922	189.9 kb	Distal (>10kb) Multiome	248
chr6:31,366,884–31,367,398	131.0 kb	Distal (>10kb) Multiome	433
chr6:31,399,631–31,400,231	98.3 kb	Distal (>10kb) Multiome	678
chr6:31,403,046–31,404,269	94.6 kb	Distal (>10kb) Multiome	796
chr6:31,441,682–31,442,105	56.3 kb	Distal (>10kb) Multiome	316
chr6:31,462,703–31,463,323	35.0 kb	Distal (>10kb) Multiome	352
chr6:31,493,848–31,494,038	841 bp	At TSS	432
chr6:31,494,174–31,494,467	412 bp	At TSS	313
chr6:31,497,638–31,498,615	17 bp	At TSS Multiome	613
chr6:31,541,205–31,542,816	44.1 kb	Distal (>10kb) Multiome	1073
chr6:31,546,485–31,547,136	48.7 kb	Distal (>10kb) Multiome	589
chr6:31,547,301–31,547,742	49.6 kb	Distal (>10kb) Multiome	762
chr6:31,580,713–31,581,330	82.9 kb	Distal (>10kb) Multiome	745
chr6:31,619,744–31,621,435	122.5 kb	Distal (>10kb) Multiome	1127
chr6:31,651,682–31,653,297	154.6 kb	Distal (>10kb) Multiome	1113
chr6:31,660,325–31,660,941	162.7 kb	Distal (>10kb) Multiome	892
chr6:31,664,725–31,666,373	166.8 kb	Distal (>10kb) Multiome	1039
chr6:31,682,887–31,683,880	185.3 kb	Distal (>10kb) Multiome	248
chr6:31,702,816–31,703,520	205.2 kb	Distal (>10kb) Multiome	875
chr6:31,728,852–31,730,814	231.5 kb	Distal (>10kb) Multiome	979
chr6:31,739,236–31,740,741	241.8 kb	Distal (>10kb) Multiome	1043
chr6:31,766,045–31,766,778	268.3 kb	Distal (>10kb) Multiome	351
chr6:31,795,097–31,796,366	297.8 kb	Distal (>10kb) Multiome	979

Genome Browser

Genomic view of the MICB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.