Enables several functions, including identical protein binding activity; phosphatidic acid binding activity; and small GTPase binding activity. Involved in several processes, including plasma membrane tubulation; protein localization to organelle; and slow endocytic recycling. Located in centriole; cilium; and endosome. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for MICALL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MICALL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MICALL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:37,608,044–37,609,455 | 297.5 kb | Distal (>10kb) Multiome | 920 | |
| chr22:37,639,157–37,639,951 | 266.7 kb | Distal (>10kb) Multiome | 427 | |
| chr22:37,658,172–37,659,508 | 247.7 kb | Distal (>10kb) Multiome | 722 | |
| chr22:37,674,916–37,675,641 | 230.9 kb | Distal (>10kb) Multiome | 607 | |
| chr22:37,676,590–37,677,674 | 229.1 kb | Distal (>10kb) Multiome | 655 | |
| chr22:37,686,104–37,686,784 | 219.9 kb | Distal (>10kb) Multiome | 866 | |
| chr22:37,696,496–37,697,685 | 209.4 kb | Distal (>10kb) Multiome | 428 | |
| chr22:37,745,641–37,746,995 | 160.1 kb | Distal (>10kb) Multiome | 627 | |
| chr22:37,802,124–37,802,989 | 103.9 kb | Distal (>10kb) Multiome | 603 | |
| chr22:37,804,679–37,805,768 | 101.1 kb | Distal (>10kb) Multiome | 763 | |
| chr22:37,807,436–37,808,267 | 98.5 kb | Distal (>10kb) Multiome | 766 | |
| chr22:37,817,672–37,819,114 | 88.4 kb | Distal (>10kb) Multiome | 713 | |
| chr22:37,824,524–37,825,593 | 81.3 kb | Distal (>10kb) Multiome | 173 | |
| chr22:37,843,748–37,844,743 | 61.9 kb | Distal (>10kb) Multiome | 798 | |
| chr22:37,849,215–37,849,709 | 56.9 kb | Distal (>10kb) Multiome | 753 | |
| chr22:37,905,849–37,906,846 | 37 bp | At TSS Multiome | 552 | |
| chr22:37,933,777–37,934,256 | 27.8 kb | Distal (>10kb) Multiome | 679 | |
| chr22:37,953,153–37,954,120 | 47.4 kb | Distal (>10kb) Multiome | 617 | |
| chr22:37,983,021–37,985,110 | 78.1 kb | Distal (>10kb) Multiome | 228 | |
| chr22:38,052,312–38,052,803 | 146.2 kb | Distal (>10kb) Multiome | 529 | |
| chr22:38,057,008–38,057,702 | 151.0 kb | Distal (>10kb) Multiome | 656 | |
| chr22:38,080,912–38,081,618 | 174.8 kb | Distal (>10kb) Multiome | 175 | |
| chr22:38,097,697–38,098,236 | 191.7 kb | Distal (>10kb) Multiome | 186 | |
| chr22:38,181,365–38,182,291 | 275.6 kb | Distal (>10kb) Multiome | 676 | |
| chr22:38,201,378–38,203,636 | 295.6 kb | Distal (>10kb) Multiome | 848 |
Genomic view of the MICALL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.