MIB2

MIB E3 ubiquitin protein ligase 2 | FLJ39787, ZZZ5, skeletrophin, ZZANK1

The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion. [provided by RefSeq, Mar 2017]

Member of: DE-9

Biological processes 21 terms

Golgi membrane (GO:0000139)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)early endosome (GO:0005769)endosome (GO:0005768)metal ion binding (GO:0046872)plasma membrane (GO:0005886)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)protein binding (GO:0005515)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)ubiquitin ligase complex (GO:0000151)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin-protein transferase activity (GO:0004842)ubiquitin-protein transferase activity (GO:0004842)ubiquitin-protein transferase activity (GO:0004842)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating MIB2 0 TFs

Transcription factors with Perturb-seq knockdown data for MIB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MIB2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:1,324,278–1,325,394	291.1 kb	Distal (>10kb) Multiome	735
chr1:1,348,716–1,350,027	266.3 kb	Distal (>10kb) Multiome	539
chr1:1,353,403–1,354,425	262.0 kb	Distal (>10kb) Multiome	276
chr1:1,374,767–1,375,798	240.5 kb	Distal (>10kb) Multiome	1113
chr1:1,398,861–1,399,955	216.4 kb	Distal (>10kb) Multiome	879
chr1:1,406,992–1,407,823	208.5 kb	Distal (>10kb) Multiome	938
chr1:1,435,318–1,436,066	180.2 kb	Distal (>10kb) Multiome	511
chr1:1,511,442–1,512,404	103.9 kb	Distal (>10kb) Multiome	897
chr1:1,540,164–1,541,317	75.2 kb	Distal (>10kb) Multiome	195
chr1:1,573,904–1,575,432	41.1 kb	Distal (>10kb) Multiome	949
chr1:1,599,945–1,600,642	15.9 kb	Distal (>10kb) Multiome	307
chr1:1,615,103–1,616,799	373 bp	At TSS Multiome	951
chr1:1,628,379–1,632,529	14.2 kb	Distal (>10kb) Multiome	552
chr1:1,658,722–1,659,418	43.3 kb	Distal (>10kb) Multiome	602
chr1:1,724,054–1,724,738	108.6 kb	Distal (>10kb) Multiome	631
chr1:1,777,637–1,780,173	162.9 kb	Distal (>10kb) Multiome	970
chr1:1,782,008–1,783,229	166.4 kb	Distal (>10kb) Multiome	590
chr1:1,883,184–1,883,831	267.7 kb	Distal (>10kb) Multiome	303
chr1:1,890,319–1,891,952	275.4 kb	Distal (>10kb) Multiome	748
chr1:1,908,308–1,910,312	293.3 kb	Distal (>10kb) Multiome	801
chr1:1,918,258–1,920,500	303.6 kb	Distal (>10kb) Multiome	820

Genome Browser

Genomic view of the MIB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.