This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]
Transcription factors with Perturb-seq knockdown data for MGST3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MGST3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MGST3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:165,355,237–165,357,320 | 274.6 kb | Distal (>10kb) Multiome | 163 | |
| chr1:165,365,159–165,365,914 | 265.7 kb | Distal (>10kb) Multiome | 151 | |
| chr1:165,375,930–165,377,162 | 254.7 kb | Distal (>10kb) Multiome | 364 | |
| chr1:165,392,768–165,393,478 | 238.1 kb | Distal (>10kb) Multiome | 462 | |
| chr1:165,443,654–165,446,226 | 186.0 kb | Distal (>10kb) Multiome | 304 | |
| chr1:165,597,953–165,599,004 | 32.9 kb | Distal (>10kb) Multiome | 625 | |
| chr1:165,630,162–165,632,376 | 222 bp | At TSS Multiome | 964 | |
| chr1:165,697,663–165,699,113 | 67.4 kb | Distal (>10kb) Multiome | 874 | |
| chr1:165,768,487–165,769,501 | 137.8 kb | Distal (>10kb) Multiome | 853 | |
| chr1:165,826,984–165,829,203 | 196.4 kb | Distal (>10kb) Multiome | 903 |
Genomic view of the MGST3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.