Enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity and manganese ion binding activity. Involved in protein O-linked glycosylation via serine. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MGAT5B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MGAT5B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MGAT5B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:76,585,404–76,586,417 | 282.5 kb | Distal (>10kb) Multiome | 591 | |
| chr17:76,612,985–76,613,550 | 255.1 kb | Distal (>10kb) Multiome | 308 | |
| chr17:76,671,049–76,672,200 | 196.7 kb | Distal (>10kb) Multiome | 947 | |
| chr17:76,708,018–76,708,518 | 160.2 kb | Distal (>10kb) Multiome | 236 | |
| chr17:76,710,928–76,711,574 | 157.3 kb | Distal (>10kb) Multiome | 421 | |
| chr17:76,725,921–76,727,506 | 141.7 kb | Distal (>10kb) Multiome | 1083 | |
| chr17:76,735,995–76,738,370 | 130.8 kb | Distal (>10kb) Multiome | 1227 | |
| chr17:76,868,004–76,869,024 | 14 bp | At TSS Multiome | 481 | |
| chr17:76,869,524–76,870,267 | 1.1 kb | Proximal (<10kb) | 125 | |
| chr17:76,968,327–76,970,292 | 100.8 kb | Distal (>10kb) Multiome | 512 | |
| chr17:77,088,470–77,089,058 | 220.3 kb | Distal (>10kb) Multiome | 979 | |
| chr17:77,139,981–77,141,779 | 272.3 kb | Distal (>10kb) Multiome | 1027 |
Genomic view of the MGAT5B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.