This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MGAT4B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MGAT4B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MGAT4B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:179,530,398–179,530,934 | 276.2 kb | Distal (>10kb) Multiome | 322 | |
| chr5:179,549,624–179,551,424 | 256.1 kb | Distal (>10kb) Multiome | 799 | |
| chr5:179,559,012–179,560,188 | 247.2 kb | Distal (>10kb) Multiome | 624 | |
| chr5:179,622,406–179,625,135 | 184.1 kb | Distal (>10kb) Multiome | 1217 | |
| chr5:179,678,118–179,679,585 | 128.3 kb | Distal (>10kb) Multiome | 1007 | |
| chr5:179,698,113–179,699,498 | 108.1 kb | Distal (>10kb) Multiome | 1062 | |
| chr5:179,732,076–179,733,697 | 74.1 kb | Distal (>10kb) Multiome | 820 | |
| chr5:179,795,059–179,796,988 | 10.6 kb | Distal (>10kb) Multiome | 778 | |
| chr5:179,801,868–179,802,100 | 4.8 kb | Proximal (<10kb) | 257 | |
| chr5:179,805,642–179,807,610 | 67 bp | At TSS Multiome | 747 | |
| chr5:179,816,597–179,817,385 | 9.7 kb | Proximal (<10kb) | 160 | |
| chr5:179,818,809–179,822,095 | 14.0 kb | Distal (>10kb) Multiome | 1243 | |
| chr5:179,858,283–179,859,465 | 52.0 kb | Distal (>10kb) Multiome | 923 | |
| chr5:179,907,372–179,908,268 | 101.1 kb | Distal (>10kb) Multiome | 528 | |
| chr5:180,007,647–180,008,169 | 201.0 kb | Distal (>10kb) Multiome | 251 | |
| chr5:180,059,605–180,060,144 | 252.9 kb | Distal (>10kb) Multiome | 18 | |
| chr5:180,069,680–180,070,372 | 263.1 kb | Distal (>10kb) Multiome | 240 | |
| chr5:180,071,104–180,072,473 | 265.1 kb | Distal (>10kb) Multiome | 1084 | |
| chr5:180,090,117–180,091,054 | 283.6 kb | Distal (>10kb) Multiome | 575 |
Genomic view of the MGAT4B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.