This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MGAT4A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MGAT4A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MGAT4A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:98,444,269–98,445,711 | 286.3 kb | Distal (>10kb) Multiome | 701 | |
| chr2:98,466,263–98,466,729 | 264.7 kb | Distal (>10kb) Multiome | 102 | |
| chr2:98,494,179–98,495,859 | 236.2 kb | Distal (>10kb) Multiome | 218 | |
| chr2:98,513,976–98,514,722 | 216.7 kb | Distal (>10kb) Multiome | 137 | |
| chr2:98,608,079–98,608,886 | 122.6 kb | Distal (>10kb) Multiome | 1004 | |
| chr2:98,611,155–98,612,164 | 119.6 kb | Distal (>10kb) Multiome | 120 | |
| chr2:98,730,234–98,731,725 | 16 bp | At TSS Multiome | 720 | |
| chr2:98,822,458–98,823,460 | 91.7 kb | Distal (>10kb) Multiome | 209 | |
| chr2:98,935,565–98,937,394 | 205.1 kb | Distal (>10kb) Multiome | 344 |
Genomic view of the MGAT4A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.