MGAT3
beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase | GNT-III

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Biological processes 19 terms
Golgi cisterna membrane (GO:0032580)Golgi membrane (GO:0000139)N-acetylglucosamine metabolic process (GO:0006044)amyloid-beta metabolic process (GO:0050435)beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity (GO:0003830)beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity (GO:0003830)beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity (GO:0003830)beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity (GO:0003830)cellular response to oxidative stress (GO:0034599)cognition (GO:0050890)glycosyltransferase activity (GO:0016757)intracellular protein localization (GO:0008104)membrane (GO:0016020)membrane (GO:0016020)negative regulation of lysosomal protein catabolic process (GO:1905166)positive regulation of protein localization to early endosome (GO:1902966)protein N-linked glycosylation (GO:0006487)protein binding (GO:0005515)regulation of cell migration (GO:0030334)
Expression (TPM)
MGAT3 — as a Regulated Gene

TFs regulating MGAT3 0 TFs

Transcription factors with Perturb-seq knockdown data for MGAT3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MGAT3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to MGAT3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MGAT3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr22:39,170,852–39,171,359 285.9 kb Distal (>10kb) Multiome 425
chr22:39,174,292–39,175,258 282.1 kb Distal (>10kb) Multiome 688
chr22:39,179,438–39,180,229 277.3 kb Distal (>10kb) Multiome 84
chr22:39,229,884–39,230,835 226.8 kb Distal (>10kb) Multiome 417
chr22:39,242,211–39,244,345 214.1 kb Distal (>10kb) Multiome 605
chr22:39,310,537–39,311,897 145.9 kb Distal (>10kb) Multiome 655
chr22:39,319,163–39,320,470 137.3 kb Distal (>10kb) Multiome 968
chr22:39,349,608–39,350,646 107.1 kb Distal (>10kb) Multiome 412
chr22:39,388,249–39,388,891 68.6 kb Distal (>10kb) Multiome 336
chr22:39,399,211–39,400,196 57.3 kb Distal (>10kb) Multiome 896
chr22:39,457,158–39,457,453 146 bp At TSS 73
chr22:39,457,629–39,458,068 617 bp At TSS 175
chr22:39,501,766–39,502,757 45.3 kb Distal (>10kb) Multiome 736
chr22:39,519,211–39,521,337 63.2 kb Distal (>10kb) Multiome 1150
chr22:39,528,868–39,529,848 72.4 kb Distal (>10kb) Multiome 829
chr22:39,532,183–39,533,171 75.8 kb Distal (>10kb) Multiome 799
chr22:39,534,113–39,535,455 78.0 kb Distal (>10kb) Multiome 621
chr22:39,598,010–39,598,521 141.3 kb Distal (>10kb) Multiome 163
chr22:39,661,773–39,663,221 205.5 kb Distal (>10kb) Multiome 260
chr22:39,663,880–39,665,145 207.7 kb Distal (>10kb) Multiome 208

Genome Browser

Genomic view of the MGAT3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr22:39,160,852 – 39,675,145
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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