Enables mRNA methyltransferase activity and tRNA (cytidine-3-)-methyltransferase activity. Involved in RNA metabolic process and positive regulation of mitochondrial translation. Is active in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for METTL8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = METTL8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of METTL8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:170,973,304–170,974,525 | 460.3 kb | Distal (>10kb) Multiome HiCAR | 906 | |
| chr2:171,159,743–171,161,450 | 273.1 kb | Distal (>10kb) Multiome HiCAR | 897 | |
| chr2:171,260,495–171,261,286 | 173.1 kb | Distal (>10kb) Multiome | 332 | |
| chr2:171,316,174–171,316,627 | 117.6 kb | Distal (>10kb) Multiome | 85 | |
| chr2:171,319,234–171,319,619 | 7.4 kb | Proximal (<10kb) | 270 | |
| chr2:171,327,008–171,327,420 | at TSS | At TSS | 98 | |
| chr2:171,433,096–171,434,895 | 156 bp | At TSS Multiome | 1119 | |
| chr2:171,522,038–171,523,908 | 88.6 kb | Distal (>10kb) Multiome | 755 | |
| chr2:171,687,283–171,688,178 | 253.6 kb | Distal (>10kb) Multiome | 886 |
Genomic view of the METTL8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.