Enables S-adenosyl-L-methionine binding activity and rRNA (adenine-N6-)-methyltransferase activity. Involved in positive regulation of translation and rRNA methylation. Located in several cellular components, including fibrillar center; postsynapse; and presynapse. Implicated in autosomal recessive intellectual developmental disorder 72. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for METTL5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = METTL5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of METTL5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:169,573,179–169,574,073 | 251.1 kb | Distal (>10kb) Multiome | 834 | |
| chr2:169,584,221–169,584,891 | 240.4 kb | Distal (>10kb) Multiome | 994 | |
| chr2:169,694,097–169,694,854 | 130.4 kb | Distal (>10kb) Multiome | 898 | |
| chr2:169,733,252–169,734,532 | 91.0 kb | Distal (>10kb) Multiome | 735 | |
| chr2:169,789,706–169,790,238 | 34.9 kb | Distal (>10kb) Multiome | 539 | |
| chr2:169,798,658–169,799,453 | 26.0 kb | Distal (>10kb) Multiome | 794 | |
| chr2:169,824,413–169,825,252 | 12 bp | At TSS Multiome | 946 | |
| chr2:169,827,076–169,828,199 | 2.5 kb | Proximal (<10kb) Multiome | 760 | |
| chr2:169,828,363–169,828,704 | 3.5 kb | Proximal (<10kb) | 262 |
Genomic view of the METTL5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.