This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for METTL2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = METTL2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of METTL2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:128,200,949–128,201,858 | 275.3 kb | Distal (>10kb) Multiome | 168 | |
| chr7:128,235,091–128,235,888 | 241.2 kb | Distal (>10kb) Multiome | 40 | |
| chr7:128,266,969–128,267,714 | 209.3 kb | Distal (>10kb) Multiome | 395 | |
| chr7:128,298,870–128,299,537 | 177.5 kb | Distal (>10kb) Multiome | 53 | |
| chr7:128,343,565–128,344,079 | 132.9 kb | Distal (>10kb) Multiome | 1136 | |
| chr7:128,350,941–128,352,858 | 124.5 kb | Distal (>10kb) Multiome | 308 | |
| chr7:128,360,334–128,361,049 | 116.0 kb | Distal (>10kb) Multiome | 282 | |
| chr7:128,361,158–128,362,317 | 115.0 kb | Distal (>10kb) Multiome | 459 | |
| chr7:128,381,074–128,381,660 | 95.4 kb | Distal (>10kb) Multiome | 156 | |
| chr7:128,387,606–128,388,141 | 88.9 kb | Distal (>10kb) Multiome | 289 | |
| chr7:128,405,316–128,406,560 | 70.7 kb | Distal (>10kb) Multiome | 559 | |
| chr7:128,409,174–128,410,630 | 66.8 kb | Distal (>10kb) Multiome | 740 | |
| chr7:128,454,251–128,454,939 | 22.2 kb | Distal (>10kb) Multiome | 220 | |
| chr7:128,455,301–128,456,353 | 20.9 kb | Distal (>10kb) Multiome | 875 | |
| chr7:128,476,406–128,477,319 | 1 bp | At TSS Multiome | 616 | |
| chr7:128,530,813–128,532,054 | 54.5 kb | Distal (>10kb) Multiome | 421 | |
| chr7:128,697,256–128,697,860 | 220.8 kb | Distal (>10kb) Multiome | 373 | |
| chr7:128,738,818–128,739,927 | 262.5 kb | Distal (>10kb) Multiome | 899 |
Genomic view of the METTL2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.