The protein encoded by this gene functions as a transcription factor regulator in the transcriptional pathway for human cognition. It is a partner of the alpha subunit of the GA-binding protein transcription factor. Mutations in this gene cause mild autosomal recessive intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Transcription factors with Perturb-seq knockdown data for METTL23. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = METTL23 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of METTL23, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:76,452,469–76,453,735 | 273.6 kb | Distal (>10kb) Multiome | 726 | |
| chr17:76,500,907–76,502,333 | 225.4 kb | Distal (>10kb) Multiome | 728 | |
| chr17:76,506,248–76,506,840 | 220.3 kb | Distal (>10kb) Multiome | 550 | |
| chr17:76,537,326–76,538,627 | 189.0 kb | Distal (>10kb) Multiome | 192 | |
| chr17:76,540,451–76,541,323 | 185.8 kb | Distal (>10kb) Multiome | 478 | |
| chr17:76,557,376–76,557,942 | 169.1 kb | Distal (>10kb) Multiome | 906 | |
| chr17:76,585,404–76,586,417 | 140.9 kb | Distal (>10kb) Multiome | 591 | |
| chr17:76,612,985–76,613,550 | 113.5 kb | Distal (>10kb) Multiome | 308 | |
| chr17:76,671,049–76,672,200 | 55.1 kb | Distal (>10kb) Multiome | 947 | |
| chr17:76,708,018–76,708,518 | 18.6 kb | Distal (>10kb) Multiome | 236 | |
| chr17:76,710,928–76,711,574 | 15.8 kb | Distal (>10kb) Multiome | 421 | |
| chr17:76,725,921–76,727,506 | 123 bp | At TSS Multiome | 1083 | |
| chr17:76,735,995–76,738,370 | 9.5 kb | Proximal (<10kb) Multiome | 1227 | |
| chr17:76,868,004–76,869,024 | 141.6 kb | Distal (>10kb) Multiome | 481 | |
| chr17:76,968,327–76,970,292 | 242.3 kb | Distal (>10kb) Multiome | 512 |
Genomic view of the METTL23 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.