Enables aminopeptidase activity. Involved in protein maturation. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for METAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = METAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of METAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:98,747,334–98,748,149 | 248.0 kb | Distal (>10kb) Multiome | 231 | |
| chr4:98,800,757–98,802,020 | 194.3 kb | Distal (>10kb) Multiome | 287 | |
| chr4:98,927,921–98,930,006 | 66.5 kb | Distal (>10kb) Multiome | 1003 | |
| chr4:98,994,750–98,996,989 | 138 bp | At TSS Multiome | 958 | |
| chr4:99,088,011–99,089,765 | 93.1 kb | Distal (>10kb) Multiome | 875 |
Genomic view of the METAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.