Predicted to be located in basement membrane and membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MEGF9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MEGF9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MEGF9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:120,533,982–120,535,010 | 180.0 kb | Distal (>10kb) Multiome | 82 | |
| chr9:120,579,589–120,580,675 | 134.3 kb | Distal (>10kb) Multiome | 900 | |
| chr9:120,713,676–120,715,795 | 113 bp | At TSS Multiome | 761 | |
| chr9:120,730,681–120,731,453 | 16.5 kb | Distal (>10kb) Multiome | 456 | |
| chr9:120,792,955–120,793,917 | 78.9 kb | Distal (>10kb) Multiome | 991 | |
| chr9:120,842,458–120,843,456 | 128.6 kb | Distal (>10kb) Multiome | 838 | |
| chr9:120,868,216–120,869,551 | 154.4 kb | Distal (>10kb) Multiome | 643 | |
| chr9:120,873,261–120,874,043 | 159.2 kb | Distal (>10kb) Multiome | 247 | |
| chr9:120,875,854–120,877,760 | 161.8 kb | Distal (>10kb) Multiome | 982 | |
| chr9:120,928,372–120,929,413 | 214.5 kb | Distal (>10kb) Multiome | 626 |
Genomic view of the MEGF9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.