This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]
Transcription factors with Perturb-seq knockdown data for MEGF10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MEGF10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MEGF10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:126,599,987–126,601,746 | 689.8 kb | Distal (>10kb) Multiome HiCAR | 911 | |
| chr5:126,674,036–126,674,611 | 616.5 kb | Distal (>10kb) Multiome HiCAR | 99 | |
| chr5:126,839,262–126,839,804 | 451.2 kb | Distal (>10kb) Multiome HiCAR | 90 | |
| chr5:127,029,529–127,031,804 | 260.1 kb | Distal (>10kb) Multiome HiCAR | 986 | |
| chr5:127,040,873–127,041,835 | 249.4 kb | Distal (>10kb) Multiome HiCAR | 329 | |
| chr5:127,072,928–127,073,820 | 217.3 kb | Distal (>10kb) Multiome HiCAR | 757 | |
| chr5:127,079,734–127,081,090 | 210.5 kb | Distal (>10kb) Multiome HiCAR | 341 | |
| chr5:127,228,773–127,229,922 | 61.4 kb | Distal (>10kb) Multiome | 517 | |
| chr5:127,289,796–127,291,714 | 248 bp | At TSS Multiome | 438 | |
| chr5:127,299,808–127,299,971 | 9.0 kb | Proximal (<10kb) | 27 | |
| chr5:127,324,468–127,325,160 | 34.1 kb | Distal (>10kb) Multiome | 115 | |
| chr5:127,517,064–127,518,431 | 226.9 kb | Distal (>10kb) Multiome HiCAR | 880 |
Genomic view of the MEGF10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.