Involved in calcium import into the mitochondrion; calcium ion import; and positive regulation of mitochondrial calcium ion concentration. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for MCUR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MCUR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MCUR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:13,532,018–13,532,632 | 282.3 kb | Distal (>10kb) Multiome | 66 | |
| chr6:13,573,806–13,575,472 | 240.1 kb | Distal (>10kb) Multiome | 1136 | |
| chr6:13,614,519–13,616,157 | 199.3 kb | Distal (>10kb) Multiome | 1137 | |
| chr6:13,710,505–13,712,451 | 102.6 kb | Distal (>10kb) Multiome | 996 | |
| chr6:13,813,584–13,814,884 | 138 bp | At TSS Multiome | 1028 | |
| chr6:13,859,849–13,861,074 | 45.9 kb | Distal (>10kb) Multiome | 81 | |
| chr6:13,873,408–13,874,382 | 59.3 kb | Distal (>10kb) Multiome | 915 | |
| chr6:13,923,928–13,925,299 | 110.3 kb | Distal (>10kb) Multiome | 566 |
Genomic view of the MCUR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.