Enables calcium channel inhibitor activity. Involved in negative regulation of calcium import into the mitochondrion. Located in cytosol and mitochondrial inner membrane. Part of uniplex complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MCUB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MCUB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MCUB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:109,301,583–109,303,714 | 257.3 kb | Distal (>10kb) Multiome | 426 | |
| chr4:109,375,427–109,376,315 | 184.3 kb | Distal (>10kb) Multiome | 86 | |
| chr4:109,386,823–109,387,310 | 173.2 kb | Distal (>10kb) Multiome | 74 | |
| chr4:109,419,054–109,420,658 | 140.4 kb | Distal (>10kb) Multiome | 227 | |
| chr4:109,433,232–109,434,512 | 126.5 kb | Distal (>10kb) Multiome | 802 | |
| chr4:109,559,632–109,561,390 | 60 bp | At TSS Multiome | 756 | |
| chr4:109,701,412–109,703,899 | 143.2 kb | Distal (>10kb) Multiome | 799 | |
| chr4:109,729,247–109,730,761 | 169.9 kb | Distal (>10kb) Multiome | 793 | |
| chr4:109,814,867–109,816,081 | 255.3 kb | Distal (>10kb) Multiome | 846 | |
| chr4:109,846,257–109,847,050 | 286.5 kb | Distal (>10kb) Multiome | 131 |
Genomic view of the MCUB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.