Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and phosphatidylserine acyl-chain remodeling. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MBOAT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MBOAT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MBOAT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:8,836,956–8,838,243 | 166.1 kb | Distal (>10kb) Multiome | 738 | |
| chr2:8,896,416–8,897,439 | 106.8 kb | Distal (>10kb) Multiome | 153 | |
| chr2:9,002,394–9,004,716 | 186 bp | At TSS Multiome | 676 | |
| chr2:9,004,904–9,005,262 | 1.2 kb | Proximal (<10kb) | 148 | |
| chr2:9,074,800–9,075,347 | 71.3 kb | Distal (>10kb) Multiome | 123 | |
| chr2:9,095,563–9,096,416 | 92.2 kb | Distal (>10kb) Multiome | 192 | |
| chr2:9,110,578–9,111,244 | 107.3 kb | Distal (>10kb) Multiome | 147 | |
| chr2:9,142,361–9,143,365 | 139.1 kb | Distal (>10kb) Multiome | 712 | |
| chr2:9,177,942–9,178,829 | 174.7 kb | Distal (>10kb) Multiome | 196 | |
| chr2:9,205,968–9,208,238 | 203.0 kb | Distal (>10kb) Multiome | 800 | |
| chr2:9,218,015–9,218,554 | 214.5 kb | Distal (>10kb) Multiome | 107 |
Genomic view of the MBOAT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.