Enables cadherin binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MB21D2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MB21D2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MB21D2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:192,700,672–192,701,436 | 216.8 kb | Distal (>10kb) Multiome | 132 | |
| chr3:192,726,996–192,728,170 | 190.3 kb | Distal (>10kb) Multiome | 320 | |
| chr3:192,788,635–192,789,830 | 128.5 kb | Distal (>10kb) Multiome | 148 | |
| chr3:192,915,047–192,915,640 | 2.2 kb | Proximal (<10kb) | 171 | |
| chr3:192,916,263–192,918,554 | 136 bp | At TSS Multiome | 705 | |
| chr3:192,920,809–192,921,074 | 3.0 kb | Proximal (<10kb) | 38 | |
| chr3:192,921,911–192,922,143 | 4.1 kb | Proximal (<10kb) | 61 | |
| chr3:192,930,670–192,931,143 | 13.0 kb | Distal (>10kb) Multiome | 150 | |
| chr3:193,190,307–193,191,034 | 272.8 kb | Distal (>10kb) Multiome | 136 |
Genomic view of the MB21D2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.