Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in bicellular tight junction assembly. Acts upstream of or within several processes, including negative regulation of JNK cascade; negative regulation of epithelial cell migration; and protein localization to cell junction. Located in bicellular tight junction and cytoplasmic vesicle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MARVELD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MARVELD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MARVELD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:71,358,510–71,359,053 | 267.5 kb | Distal (>10kb) Multiome | 387 | |
| chr16:71,412,167–71,413,209 | 213.5 kb | Distal (>10kb) Multiome | 349 | |
| chr16:71,425,887–71,427,162 | 199.7 kb | Distal (>10kb) Multiome | 924 | |
| chr16:71,441,362–71,442,080 | 184.5 kb | Distal (>10kb) Multiome | 232 | |
| chr16:71,461,920–71,462,398 | 163.9 kb | Distal (>10kb) Multiome | 944 | |
| chr16:71,484,066–71,484,742 | 141.8 kb | Distal (>10kb) Multiome | 801 | |
| chr16:71,526,040–71,526,860 | 99.7 kb | Distal (>10kb) Multiome | 294 | |
| chr16:71,564,628–71,565,649 | 61.1 kb | Distal (>10kb) Multiome | 792 | |
| chr16:71,625,835–71,627,289 | 18 bp | At TSS Multiome | 594 | |
| chr16:71,722,829–71,724,442 | 97.0 kb | Distal (>10kb) Multiome | 894 | |
| chr16:71,808,251–71,809,603 | 183.0 kb | Distal (>10kb) Multiome | 1032 | |
| chr16:71,845,428–71,846,392 | 219.8 kb | Distal (>10kb) Multiome | 923 | |
| chr16:71,883,009–71,884,742 | 258.0 kb | Distal (>10kb) Multiome | 791 | |
| chr16:71,894,288–71,896,022 | 269.2 kb | Distal (>10kb) Multiome | 1139 |
Genomic view of the MARVELD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.