This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for MARCKSL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MARCKSL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MARCKSL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:32,072,319–32,073,738 | 263.1 kb | Distal (>10kb) Multiome | 909 | |
| chr1:32,107,881–32,108,706 | 228.1 kb | Distal (>10kb) Multiome | 779 | |
| chr1:32,179,263–32,180,190 | 156.5 kb | Distal (>10kb) Multiome | 1019 | |
| chr1:32,200,233–32,201,756 | 135.6 kb | Distal (>10kb) Multiome | 573 | |
| chr1:32,204,985–32,206,258 | 130.7 kb | Distal (>10kb) Multiome | 679 | |
| chr1:32,221,877–32,222,889 | 113.9 kb | Distal (>10kb) Multiome | 755 | |
| chr1:32,239,728–32,240,979 | 95.9 kb | Distal (>10kb) Multiome | 456 | |
| chr1:32,248,081–32,248,895 | 87.8 kb | Distal (>10kb) Multiome | 622 | |
| chr1:32,291,710–32,292,726 | 44.2 kb | Distal (>10kb) Multiome | 900 | |
| chr1:32,334,713–32,336,836 | 29 bp | At TSS Multiome | 804 | |
| chr1:32,351,055–32,352,355 | 15.3 kb | Distal (>10kb) Multiome | 944 | |
| chr1:32,361,365–32,362,459 | 25.9 kb | Distal (>10kb) Multiome | 305 | |
| chr1:32,393,928–32,395,356 | 58.4 kb | Distal (>10kb) Multiome | 930 | |
| chr1:32,437,702–32,438,502 | 102.0 kb | Distal (>10kb) Multiome | 85 | |
| chr1:32,439,697–32,440,223 | 103.7 kb | Distal (>10kb) Multiome | 40 | |
| chr1:32,464,697–32,465,552 | 128.8 kb | Distal (>10kb) Multiome | 408 | |
| chr1:32,500,363–32,501,049 | 164.5 kb | Distal (>10kb) Multiome | 540 | |
| chr1:32,520,498–32,520,989 | 184.5 kb | Distal (>10kb) Multiome | 384 | |
| chr1:32,539,285–32,540,081 | 203.5 kb | Distal (>10kb) Multiome | 434 | |
| chr1:32,540,505–32,541,033 | 204.6 kb | Distal (>10kb) Multiome | 172 | |
| chr1:32,611,983–32,612,668 | 276.1 kb | Distal (>10kb) Multiome | 560 |
Genomic view of the MARCKSL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.