The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for MAPKAPK5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAPKAPK5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAPKAPK5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:111,597,725–111,600,125 | 242.6 kb | Distal (>10kb) Multiome | 973 | |
| chr12:111,685,452–111,686,504 | 156.2 kb | Distal (>10kb) Multiome | 858 | |
| chr12:111,766,539–111,767,436 | 75.3 kb | Distal (>10kb) Multiome | 732 | |
| chr12:111,775,668–111,776,178 | 66.2 kb | Distal (>10kb) Multiome | 448 | |
| chr12:111,841,636–111,842,766 | 146 bp | At TSS Multiome | 963 | |
| chr12:111,967,710–111,968,344 | 125.9 kb | Distal (>10kb) Multiome | 26 | |
| chr12:112,012,418–112,014,496 | 171.1 kb | Distal (>10kb) Multiome | 1077 | |
| chr12:112,108,135–112,109,541 | 266.6 kb | Distal (>10kb) Multiome | 788 | |
| chr12:112,116,420–112,116,883 | 274.5 kb | Distal (>10kb) Multiome | 549 | |
| chr12:112,125,273–112,125,989 | 283.3 kb | Distal (>10kb) Multiome | 798 |
Genomic view of the MAPKAPK5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.