The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Transcription factors with Perturb-seq knockdown data for MAPK10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAPK10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAPK10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:86,309,328–86,310,316 | 284.1 kb | Distal (>10kb) Multiome | 57 | |
| chr4:86,359,993–86,360,421 | at TSS | At TSS | 252 | |
| chr4:86,368,829–86,369,226 | 8.7 kb | Proximal (<10kb) | 14 | |
| chr4:86,403,273–86,403,939 | 190.3 kb | Distal (>10kb) Multiome | 107 | |
| chr4:86,472,460–86,473,001 | 121.3 kb | Distal (>10kb) Multiome | 124 | |
| chr4:86,476,047–86,476,574 | 117.9 kb | Distal (>10kb) Multiome | 43 | |
| chr4:86,476,717–86,477,944 | 116.6 kb | Distal (>10kb) Multiome | 85 | |
| chr4:86,482,713–86,483,298 | 111.0 kb | Distal (>10kb) Multiome | 239 | |
| chr4:86,587,165–86,588,064 | 6.0 kb | Proximal (<10kb) | 147 | |
| chr4:86,593,672–86,595,457 | 172 bp | At TSS Multiome | 633 | |
| chr4:86,891,788–86,892,917 | 298.2 kb | Distal (>10kb) Multiome | 698 |
Genomic view of the MAPK10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.