The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Transcription factors with Perturb-seq knockdown data for MAP7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:136,249,441–136,251,347 | 300.0 kb | Distal (>10kb) Multiome | 921 | |
| chr6:136,288,756–136,290,871 | 260.5 kb | Distal (>10kb) Multiome | 1158 | |
| chr6:136,499,147–136,499,983 | 50.8 kb | Distal (>10kb) Multiome | 207 | |
| chr6:136,526,121–136,527,142 | 23.8 kb | Distal (>10kb) Multiome | 235 | |
| chr6:136,549,356–136,551,131 | 149 bp | At TSS Multiome | 722 | |
| chr6:136,551,225–136,551,408 | 803 bp | At TSS | 55 | |
| chr6:136,791,271–136,793,463 | 242.6 kb | Distal (>10kb) Multiome | 880 | |
| chr6:136,822,046–136,823,437 | 272.3 kb | Distal (>10kb) Multiome | 679 |
Genomic view of the MAP7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.