The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MAP3K2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP3K2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP3K2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:127,105,209–127,108,284 | 280.7 kb | Distal (>10kb) Multiome | 594 | |
| chr2:127,218,704–127,220,652 | 168.0 kb | Distal (>10kb) Multiome | 316 | |
| chr2:127,293,716–127,294,914 | 93.8 kb | Distal (>10kb) Multiome | 876 | |
| chr2:127,386,971–127,388,844 | 575 bp | At TSS Multiome | 986 | |
| chr2:127,407,631–127,408,983 | 20.2 kb | Distal (>10kb) Multiome | 878 | |
| chr2:127,415,703–127,416,595 | 28.1 kb | Distal (>10kb) Multiome | 501 | |
| chr2:127,422,503–127,423,812 | 35.3 kb | Distal (>10kb) Multiome | 321 | |
| chr2:127,463,310–127,464,007 | 75.7 kb | Distal (>10kb) Multiome | 176 | |
| chr2:127,525,984–127,528,084 | 138.6 kb | Distal (>10kb) Multiome | 1026 | |
| chr2:127,542,311–127,543,476 | 155.2 kb | Distal (>10kb) Multiome | 233 | |
| chr2:127,591,279–127,591,967 | 203.6 kb | Distal (>10kb) Multiome | 431 | |
| chr2:127,674,653–127,675,849 | 287.3 kb | Distal (>10kb) Multiome | 324 |
Genomic view of the MAP3K2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.