This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MAP3K14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP3K14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP3K14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:45,021,768–45,022,248 | 294.9 kb | Distal (>10kb) Multiome | 739 | |
| chr17:45,051,210–45,051,755 | 265.5 kb | Distal (>10kb) Multiome | 771 | |
| chr17:45,060,587–45,061,694 | 255.8 kb | Distal (>10kb) Multiome | 979 | |
| chr17:45,131,590–45,133,655 | 183.6 kb | Distal (>10kb) Multiome | 898 | |
| chr17:45,135,189–45,136,052 | 181.5 kb | Distal (>10kb) Multiome | 930 | |
| chr17:45,143,207–45,145,183 | 173.2 kb | Distal (>10kb) Multiome | 308 | |
| chr17:45,147,066–45,150,271 | 169.6 kb | Distal (>10kb) Multiome | 1345 | |
| chr17:45,160,688–45,162,340 | 155.4 kb | Distal (>10kb) Multiome | 1200 | |
| chr17:45,197,493–45,198,189 | 119.1 kb | Distal (>10kb) Multiome | 835 | |
| chr17:45,241,380–45,242,217 | 75.2 kb | Distal (>10kb) Multiome | 131 | |
| chr17:45,246,828–45,248,615 | 69.3 kb | Distal (>10kb) Multiome | 858 | |
| chr17:45,261,690–45,262,406 | 55.0 kb | Distal (>10kb) Multiome | 234 | |
| chr17:45,316,202–45,317,910 | 158 bp | At TSS Multiome | 857 | |
| chr17:45,334,174–45,334,847 | 17.4 kb | Distal (>10kb) Multiome | 149 | |
| chr17:45,371,481–45,372,140 | 54.8 kb | Distal (>10kb) Multiome | 704 | |
| chr17:45,395,009–45,395,645 | 78.3 kb | Distal (>10kb) Multiome | 482 | |
| chr17:45,404,953–45,406,129 | 88.5 kb | Distal (>10kb) Multiome | 244 | |
| chr17:45,425,403–45,426,061 | 108.8 kb | Distal (>10kb) Multiome | 506 | |
| chr17:45,427,967–45,428,575 | 111.2 kb | Distal (>10kb) Multiome | 454 | |
| chr17:45,429,511–45,430,237 | 112.8 kb | Distal (>10kb) Multiome | 190 | |
| chr17:45,431,253–45,432,633 | 114.7 kb | Distal (>10kb) Multiome | 435 |
Genomic view of the MAP3K14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.