MAP3K10

mitogen-activated protein kinase kinase kinase 10 | MEKK10, MST, MLK2

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]

Member of: DE-5 DE-5.2 Developmental clusters: GC6

Biological processes 23 terms

ATP binding (GO:0005524)JNK cascade (GO:0007254)JUN kinase kinase kinase activity (GO:0004706)JUN kinase kinase kinase activity (GO:0004706)MAP kinase kinase kinase activity (GO:0004709)apoptotic process (GO:0006915)bHLH transcription factor binding (GO:0043425)cytoplasm (GO:0005737)cytoplasm (GO:0005737)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of transcription by RNA polymerase II (GO:0000122)positive regulation of JNK cascade (GO:0046330)positive regulation of apoptotic process (GO:0043065)positive regulation of apoptotic process (GO:0043065)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein kinase activity (GO:0004672)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)signal transduction (GO:0007165)smoothened signaling pathway (GO:0007224)transcription corepressor activity (GO:0003714)transcription corepressor activity (GO:0003714)

Expression (TPM)

TFs regulating MAP3K10 0 TFs

Transcription factors with Perturb-seq knockdown data for MAP3K10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP3K10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MAP3K10

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP3K10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:39,970,370–39,971,611	220.4 kb	Distal (>10kb) Multiome	930
chr19:39,996,681–39,997,502	194.4 kb	Distal (>10kb) Multiome	898
chr19:40,055,898–40,056,369	135.3 kb	Distal (>10kb) Multiome	746
chr19:40,090,491–40,091,099	100.6 kb	Distal (>10kb) Multiome	831
chr19:40,190,883–40,192,408	444 bp	At TSS Multiome	764
chr19:40,217,060–40,217,642	25.8 kb	Distal (>10kb) Multiome	366
chr19:40,284,527–40,285,917	93.9 kb	Distal (>10kb) Multiome	913
chr19:40,347,917–40,348,964	157.1 kb	Distal (>10kb) Multiome	843
chr19:40,365,649–40,366,111	174.4 kb	Distal (>10kb) Multiome	244
chr19:40,398,541–40,399,285	207.5 kb	Distal (>10kb) Multiome	234
chr19:40,403,323–40,404,681	212.2 kb	Distal (>10kb) Multiome	638
chr19:40,420,702–40,421,699	229.7 kb	Distal (>10kb) Multiome	966
chr19:40,424,783–40,426,631	234.5 kb	Distal (>10kb) Multiome	954
chr19:40,433,505–40,434,546	242.6 kb	Distal (>10kb) Multiome	791
chr19:40,442,698–40,445,144	251.8 kb	Distal (>10kb) Multiome	994
chr19:40,465,326–40,466,635	274.5 kb	Distal (>10kb) Multiome	815
chr19:40,487,850–40,488,306	296.7 kb	Distal (>10kb) Multiome	193

Genome Browser

Genomic view of the MAP3K10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.