This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MAP1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:72,057,600–72,058,552 | 49.4 kb | Distal (>10kb) Multiome | 65 | |
| chr5:72,065,796–72,066,276 | 41.4 kb | Distal (>10kb) Multiome | 107 | |
| chr5:72,106,794–72,109,078 | 1.3 kb | Proximal (<10kb) Multiome | 816 | |
| chr5:72,307,892–72,308,896 | 200.9 kb | Distal (>10kb) Multiome | 956 | |
| chr5:72,319,763–72,320,908 | 212.9 kb | Distal (>10kb) Multiome | 876 |
Genomic view of the MAP1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.