Predicted to enable alpha-mannosidase activity. Predicted to be involved in mannose metabolic process and oligosaccharide catabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MAN2B2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAN2B2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAN2B2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:6,308,663–6,309,660 | 266.0 kb | Distal (>10kb) Multiome | 421 | |
| chr4:6,327,148–6,327,740 | 247.7 kb | Distal (>10kb) Multiome | 371 | |
| chr4:6,367,437–6,367,936 | 207.5 kb | Distal (>10kb) Multiome | 38 | |
| chr4:6,470,551–6,471,324 | 104.3 kb | Distal (>10kb) Multiome | 373 | |
| chr4:6,472,122–6,472,949 | 102.6 kb | Distal (>10kb) Multiome | 157 | |
| chr4:6,574,723–6,575,464 | 83 bp | At TSS Multiome | 601 | |
| chr4:6,583,174–6,583,399 | 8.0 kb | Proximal (<10kb) | 112 | |
| chr4:6,640,089–6,641,132 | 65.4 kb | Distal (>10kb) Multiome | 851 | |
| chr4:6,673,157–6,674,688 | 98.8 kb | Distal (>10kb) Multiome | 920 | |
| chr4:6,709,388–6,710,099 | 134.7 kb | Distal (>10kb) Multiome | 693 | |
| chr4:6,715,775–6,716,910 | 141.0 kb | Distal (>10kb) Multiome | 822 | |
| chr4:6,782,106–6,784,027 | 207.4 kb | Distal (>10kb) Multiome | 886 |
Genomic view of the MAN2B2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.