This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013]
Transcription factors with Perturb-seq knockdown data for MAN2A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAN2A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAN2A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:109,688,464–109,691,494 | 164.1 kb | Distal (>10kb) Multiome | 1024 | |
| chr5:109,743,168–109,744,398 | 109.7 kb | Distal (>10kb) Multiome | 354 | |
| chr5:109,805,916–109,806,444 | 47.5 kb | Distal (>10kb) Multiome | 134 | |
| chr5:109,857,449–109,858,346 | 3.9 kb | Proximal (<10kb) | 79 | |
| chr5:109,916,762–109,917,682 | 63.7 kb | Distal (>10kb) Multiome | 128 |
Genomic view of the MAN2A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.