Predicted to enable glycosaminoglycan binding activity. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MAMDC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAMDC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAMDC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:69,759,439–69,760,486 | 283.9 kb | Distal (>10kb) Multiome | 751 | |
| chr9:69,820,343–69,821,096 | 223.1 kb | Distal (>10kb) Multiome | 239 | |
| chr9:69,823,108–69,824,042 | 220.2 kb | Distal (>10kb) Multiome | 59 | |
| chr9:69,986,283–69,987,113 | 57.1 kb | Distal (>10kb) Multiome | 65 | |
| chr9:70,043,398–70,045,147 | 988 bp | At TSS Multiome | 310 | |
| chr9:70,053,786–70,054,155 | 9.9 kb | Proximal (<10kb) | 100 | |
| chr9:70,256,089–70,256,627 | 212.5 kb | Distal (>10kb) Multiome | 140 | |
| chr9:70,258,134–70,259,705 | 215.0 kb | Distal (>10kb) Multiome | 919 |
Genomic view of the MAMDC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.