Enables mitochondrial large ribosomal subunit binding activity. Involved in negative regulation of mitochondrial translation and ribosomal large subunit biogenesis. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MALSU1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MALSU1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MALSU1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:23,013,184–23,014,464 | 285.1 kb | Distal (>10kb) Multiome | 751 | |
| chr7:23,105,409–23,106,715 | 193.6 kb | Distal (>10kb) Multiome | 833 | |
| chr7:23,116,020–23,116,472 | 183.2 kb | Distal (>10kb) Multiome | 105 | |
| chr7:23,181,578–23,182,460 | 117.4 kb | Distal (>10kb) Multiome | 935 | |
| chr7:23,205,915–23,206,590 | 93.1 kb | Distal (>10kb) Multiome | 154 | |
| chr7:23,247,362–23,248,065 | 51.6 kb | Distal (>10kb) Multiome | 202 | |
| chr7:23,299,105–23,299,994 | 22 bp | At TSS Multiome | 852 | |
| chr7:23,465,333–23,465,840 | 166.2 kb | Distal (>10kb) Multiome | 410 | |
| chr7:23,470,190–23,471,917 | 172.0 kb | Distal (>10kb) Multiome | 922 | |
| chr7:23,473,588–23,475,134 | 175.1 kb | Distal (>10kb) Multiome | 996 | |
| chr7:23,531,132–23,532,637 | 232.7 kb | Distal (>10kb) Multiome HiCAR | 1024 | |
| chr7:23,596,997–23,598,169 | 298.1 kb | Distal (>10kb) Multiome | 879 |
Genomic view of the MALSU1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.