Enables RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MAK16. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAK16 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAK16, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:33,187,460–33,188,474 | 297.1 kb | Distal (>10kb) Multiome | 176 | |
| chr8:33,223,201–33,224,129 | 261.6 kb | Distal (>10kb) Multiome | 103 | |
| chr8:33,471,825–33,473,740 | 12.0 kb | Distal (>10kb) Multiome | 999 | |
| chr8:33,484,346–33,485,645 | 183 bp | At TSS Multiome | 940 | |
| chr8:33,512,345–33,515,139 | 29.5 kb | Distal (>10kb) Multiome | 1310 | |
| chr8:33,543,087–33,543,854 | 58.2 kb | Distal (>10kb) Multiome | 102 | |
| chr8:33,566,077–33,567,716 | 82.0 kb | Distal (>10kb) Multiome | 711 | |
| chr8:33,626,086–33,627,037 | 141.2 kb | Distal (>10kb) Multiome | 118 |
Genomic view of the MAK16 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.