Transcription factors with Perturb-seq knockdown data for MAILR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAILR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAILR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:102,653,614–102,656,985 | 276.1 kb | Distal (>10kb) Multiome | 1123 | |
| chr8:102,806,122–102,807,887 | 122.6 kb | Distal (>10kb) Multiome | 1159 | |
| chr8:102,810,067–102,811,695 | 119.4 kb | Distal (>10kb) Multiome | 1025 | |
| chr8:102,814,226–102,814,970 | 115.4 kb | Distal (>10kb) Multiome | 366 | |
| chr8:102,862,625–102,865,007 | 65.8 kb | Distal (>10kb) Multiome | 1106 | |
| chr8:102,906,209–102,906,703 | 23.8 kb | Distal (>10kb) Multiome | 254 | |
| chr8:102,929,841–102,930,216 | at TSS | At TSS | 144 | |
| chr8:102,961,399–102,961,996 | 31.4 kb | Distal (>10kb) Multiome | 268 | |
| chr8:103,020,472–103,021,647 | 90.8 kb | Distal (>10kb) Multiome | 842 | |
| chr8:103,140,428–103,141,578 | 210.7 kb | Distal (>10kb) Multiome | 259 |
Genomic view of the MAILR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.