Predicted to enable frizzled binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within positive regulation of JUN kinase activity. Located in cell junction. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for MAGI3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAGI3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAGI3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:113,140,616–113,141,422 | 249.5 kb | Distal (>10kb) Multiome HiCAR | 413 | |
| chr1:113,217,521–113,218,452 | 172.5 kb | Distal (>10kb) Multiome HiCAR | 479 | |
| chr1:113,223,494–113,224,107 | 166.7 kb | Distal (>10kb) Multiome | 75 | |
| chr1:113,234,064–113,234,645 | 156.1 kb | Distal (>10kb) Multiome | 67 | |
| chr1:113,252,166–113,252,950 | 138.1 kb | Distal (>10kb) Multiome | 98 | |
| chr1:113,389,436–113,391,612 | 243 bp | At TSS Multiome | 815 |
Genomic view of the MAGI3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.