This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]
Transcription factors with Perturb-seq knockdown data for LZTS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LZTS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LZTS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:20,196,723–20,198,840 | 105.3 kb | Distal (>10kb) Multiome | 908 | |
| chr8:20,233,433–20,235,922 | 69.2 kb | Distal (>10kb) Multiome HiCAR | 438 | |
| chr8:20,268,136–20,269,428 | 35.6 kb | Distal (>10kb) Multiome | 402 | |
| chr8:20,288,802–20,289,605 | 14.7 kb | Distal (>10kb) Multiome | 28 | |
| chr8:20,303,205–20,304,353 | 68 bp | At TSS Multiome | 352 | |
| chr8:20,310,894–20,311,352 | 6.9 kb | Proximal (<10kb) | 127 | |
| chr8:20,312,907–20,313,367 | 8.9 kb | Proximal (<10kb) | 71 | |
| chr8:20,327,805–20,328,767 | 24.4 kb | Distal (>10kb) Multiome | 129 | |
| chr8:20,352,955–20,355,223 | 51.1 kb | Distal (>10kb) Multiome HiCAR | 316 | |
| chr8:20,362,692–20,363,243 | 58.9 kb | Distal (>10kb) Multiome HiCAR | 52 | |
| chr8:20,434,902–20,436,096 | 131.6 kb | Distal (>10kb) Multiome | 349 | |
| chr8:20,458,168–20,458,743 | 154.5 kb | Distal (>10kb) Multiome | 138 | |
| chr8:21,782,177–21,783,108 | 1478.8 kb | Distal (>10kb) Multiome HiCAR | 145 | |
| chr8:21,784,384–21,784,867 | 1480.6 kb | Distal (>10kb) Multiome HiCAR | 246 | |
| chr8:21,788,264–21,790,181 | 1485.0 kb | Distal (>10kb) Multiome HiCAR | 307 |
Genomic view of the LZTS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.