Enables peptidoglycan binding activity. Involved in Golgi organization. Located in Golgi membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LYSMD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LYSMD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LYSMD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:90,408,713–90,410,622 | 119.7 kb | Distal (>10kb) Multiome | 999 | |
| chr5:90,473,267–90,475,425 | 54.9 kb | Distal (>10kb) Multiome | 1125 | |
| chr5:90,476,971–90,477,623 | 52.3 kb | Distal (>10kb) Multiome | 165 | |
| chr5:90,528,730–90,530,341 | 118 bp | At TSS Multiome | 946 | |
| chr5:90,557,815–90,559,398 | 29.2 kb | Distal (>10kb) Multiome | 611 |
Genomic view of the LYSMD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.