The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for LYRM4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LYRM4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LYRM4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:5,003,235–5,004,614 | 257.1 kb | Distal (>10kb) Multiome | 925 | |
| chr6:5,025,821–5,026,808 | 234.6 kb | Distal (>10kb) Multiome | 434 | |
| chr6:5,036,286–5,036,731 | 224.5 kb | Distal (>10kb) Multiome | 261 | |
| chr6:5,084,296–5,086,827 | 174.8 kb | Distal (>10kb) Multiome | 640 | |
| chr6:5,260,007–5,261,755 | 197 bp | At TSS Multiome | 931 | |
| chr6:5,438,974–5,439,475 | 178.2 kb | Distal (>10kb) Multiome | 67 |
Genomic view of the LYRM4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.